btw non selective COX inhibitor 都會increase cvs risk. 2015 年FDA 都updated 左個warnings.
https://www.fda.gov/Drugs/DrugSafety/ucm451800.htm
UpToDate:
The use of nonsteroidal antiinflammatory drugs (NSAIDs) is associated with an increased risk of adverse cardiovascular events. Both nonselective NSAIDs and cyclooxygenase (COX)-2 selective NSAIDs (coxibs) increase the risk of such events. Although the risk of adverse cardiovascular events is heterogeneous across NSAIDs, the precise absolute and relative risk data for many of these agents are limited.