2017 DSE Bio 討論區(2)

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2017-04-23 21:29:28
Why gene therapy cannot cure dominant disease?

You should bear in mind that the transferred normal gene is not a replacement of the defective gene. It is used to compensate for the defective gene. If the normal gene is dominant over disease-causing gene, the effect of the disease-causing gene will be masked.

If that is the case, the allele for the genetic defect cannot be dominant, because the dominant allele will still expressed even if a normal gene is introduced.
2017-04-23 21:34:14
打得快手冇proofread,你有唔明再問
2017-04-23 21:38:16
咁recessive disease 一樣?

基於佢係做compensation, not replacement

Recessive defective gene 一樣被expressed
2017-04-23 21:40:34
咁recessive disease 一樣?

基於佢係做compensation, not replacement

Recessive defective gene 一樣被expressed

我點知normal allele over disease-causing allele ?

Like note said, we usually treat recessive disease

咁introduce normal allele, 點知normal allele is dominant over disease-causing recessive allele?
2017-04-23 21:41:18
咁recessive disease 一樣?

基於佢係做compensation, not replacement

Recessive defective gene 一樣被expressed


The newly introduced normal gene into the body will be dominant if the disease-causing gene is recessive.
The effect of disease-causing gene is masked.
2017-04-23 21:42:12
咁recessive disease 一樣?

基於佢係做compensation, not replacement

Recessive defective gene 一樣被expressed


The newly introduced normal gene into the body will be dominant if the disease-causing gene is recessive.
The effect of disease-causing gene is masked.


老師無教過,學到野
麻煩曬
2017-04-23 21:43:45
咁recessive disease 一樣?

基於佢係做compensation, not replacement

Recessive defective gene 一樣被expressed

我點知normal allele over disease-causing allele ?

Like note said, we usually treat recessive disease

咁introduce normal allele, 點知normal allele is dominant over disease-causing recessive allele?


咁呢個係疾病本身嘅特質嚟架嘛。例如colour blindness係X-linked recessive咁呢樣野唔會變架嘛。
2017-04-23 21:47:26
咁recessive disease 一樣?

基於佢係做compensation, not replacement

Recessive defective gene 一樣被expressed

我點知normal allele over disease-causing allele ?

Like note said, we usually treat recessive disease

咁introduce normal allele, 點知normal allele is dominant over disease-causing recessive allele?


咁呢個係疾病本身嘅特質嚟架嘛。例如colour blindness係X-linked recessive咁呢樣野唔會變架嘛。

但我始終有個錯概念

我e4多問題 唔好介意 thanks

Viral vector 其實"infected"
-> viral DNA insertion into cells with defective gene
-> 「亂插」,唔可能replace defective gene
-> 咁有無可能defective gene in like 10th chromosome; normal gene inserted into 20th chromosome?
2017-04-23 21:49:49
Gene therapy will provide DNA to substitue the chromosome with disease causing gene ?
2017-04-23 21:55:13
Why gene therapy cannot cure dominant disease?

You should bear in mind that the transferred normal gene is not a replacement of the defective gene. It is used to compensate for the defective gene. If the normal gene is dominant over disease-causing gene, the effect of the disease-causing gene will be masked.

If that is the case, the allele for the genetic defect cannot be dominant, because the dominant allele will still expressed even if a normal gene is introduced.

Compensate 啫係點?我唔明分別喺係邊?
2017-04-23 21:55:42
咁recessive disease 一樣?

基於佢係做compensation, not replacement

Recessive defective gene 一樣被expressed

我點知normal allele over disease-causing allele ?

Like note said, we usually treat recessive disease

咁introduce normal allele, 點知normal allele is dominant over disease-causing recessive allele?


咁呢個係疾病本身嘅特質嚟架嘛。例如colour blindness係X-linked recessive咁呢樣野唔會變架嘛。

但我始終有個錯概念

我e4多問題 唔好介意 thanks

Viral vector 其實"infected"
-> viral DNA insertion into cells with defective gene
-> 「亂插」,唔可能replace defective gene
-> 咁有無可能defective gene in like 10th chromosome; normal gene inserted into 20th chromosome?


有可能嫁,DSE一早考過potential hazards of gene therapy呢個位,仲要係2015年炸嘛。
你冇睇到pastpaper咩?
2017-04-23 21:57:16
咁recessive disease 一樣?

基於佢係做compensation, not replacement

Recessive defective gene 一樣被expressed

我點知normal allele over disease-causing allele ?

Like note said, we usually treat recessive disease

咁introduce normal allele, 點知normal allele is dominant over disease-causing recessive allele?


咁呢個係疾病本身嘅特質嚟架嘛。例如colour blindness係X-linked recessive咁呢樣野唔會變架嘛。

但我始終有個錯概念

我e4多問題 唔好介意 thanks

Viral vector 其實"infected"
-> viral DNA insertion into cells with defective gene
-> 「亂插」,唔可能replace defective gene
-> 咁有無可能defective gene in like 10th chromosome; normal gene inserted into 20th chromosome?


有可能嫁,DSE一早考過potential hazards of gene therapy呢個位,仲要係2015年炸嘛。
你冇睇到pastpaper咩?


我只係唔知唔同chromosomes
仲express到?
2017-04-23 21:58:10
Why gene therapy cannot cure dominant disease?

You should bear in mind that the transferred normal gene is not a replacement of the defective gene. It is used to compensate for the defective gene. If the normal gene is dominant over disease-causing gene, the effect of the disease-causing gene will be masked.

If that is the case, the allele for the genetic defect cannot be dominant, because the dominant allele will still expressed even if a normal gene is introduced.

Compensate 啫係點?我唔明分別喺係邊?


姐係類似抵消。唔同取代。
生活例子:你嘅長處抵消你嘅短處,唔代表你嘅短處消失左。
2017-04-23 22:00:26
咁recessive disease 一樣?

基於佢係做compensation, not replacement

Recessive defective gene 一樣被expressed

我點知normal allele over disease-causing allele ?

Like note said, we usually treat recessive disease

咁introduce normal allele, 點知normal allele is dominant over disease-causing recessive allele?


咁呢個係疾病本身嘅特質嚟架嘛。例如colour blindness係X-linked recessive咁呢樣野唔會變架嘛。

但我始終有個錯概念

我e4多問題 唔好介意 thanks

Viral vector 其實"infected"
-> viral DNA insertion into cells with defective gene
-> 「亂插」,唔可能replace defective gene
-> 咁有無可能defective gene in like 10th chromosome; normal gene inserted into 20th chromosome?


有可能嫁,DSE一早考過potential hazards of gene therapy呢個位,仲要係2015年炸嘛。
你冇睇到pastpaper咩?


我只係唔知唔同chromosomes
仲express到?


呢啲位唔洗深究,總之你正正常常跟返syllabus。 都已經呢個時候。
2017-04-23 22:01:13
咁recessive disease 一樣?

基於佢係做compensation, not replacement

Recessive defective gene 一樣被expressed

我點知normal allele over disease-causing allele ?

Like note said, we usually treat recessive disease

咁introduce normal allele, 點知normal allele is dominant over disease-causing recessive allele?


咁呢個係疾病本身嘅特質嚟架嘛。例如colour blindness係X-linked recessive咁呢樣野唔會變架嘛。

但我始終有個錯概念

我e4多問題 唔好介意 thanks

Viral vector 其實"infected"
-> viral DNA insertion into cells with defective gene
-> 「亂插」,唔可能replace defective gene
-> 咁有無可能defective gene in like 10th chromosome; normal gene inserted into 20th chromosome?


有可能嫁,DSE一早考過potential hazards of gene therapy呢個位,仲要係2015年炸嘛。
你冇睇到pastpaper咩?


我只係唔知唔同chromosomes
仲express到?


呢啲位唔洗深究,總之你正正常常跟返syllabus。 都已經呢個時候。

收到
多謝建議
2017-04-23 22:02:25
Why gene therapy cannot cure dominant disease?

You should bear in mind that the transferred normal gene is not a replacement of the defective gene. It is used to compensate for the defective gene. If the normal gene is dominant over disease-causing gene, the effect of the disease-causing gene will be masked.

If that is the case, the allele for the genetic defect cannot be dominant, because the dominant allele will still expressed even if a normal gene is introduced.

Compensate 啫係點?我唔明分別喺係邊?


姐係類似抵消。唔同取代。
生活例子:你嘅長處抵消你嘅短處,唔代表你嘅短處消失左。

如果以 Sickle cell anaemia 為例,即係gene therapy 之後, sickle shaped RBC 依舊produce, 但係正常嘅 RBC 都會produce, 所以抵消左??
2017-04-23 22:03:21
Why gene therapy cannot cure dominant disease?

You should bear in mind that the transferred normal gene is not a replacement of the defective gene. It is used to compensate for the defective gene. If the normal gene is dominant over disease-causing gene, the effect of the disease-causing gene will be masked.

If that is the case, the allele for the genetic defect cannot be dominant, because the dominant allele will still expressed even if a normal gene is introduced.

Compensate 啫係點?我唔明分別喺係邊?


姐係類似抵消。唔同取代。
生活例子:你嘅長處抵消你嘅短處,唔代表你嘅短處消失左。

如果以 Sickle cell anaemia 為例,即係gene therapy 之後, sickle shaped RBC 依舊produce, 但係正常嘅 RBC 都會produce, 所以抵消左??


因為有extra functional protein
2017-04-23 22:03:59
Gene therapy will provide DNA to substitue the chromosome with disease causing gene ?


In gene therapy, the normal gene (which is dominant) is introduced into the target somatic cells to compensate the recessive disease-causing gene.

唔用亂用字啦,呢個時候唔好玩野挑戰考評局。
Substitute/Replace no way.
2017-04-23 22:05:21
Why gene therapy cannot cure dominant disease?

You should bear in mind that the transferred normal gene is not a replacement of the defective gene. It is used to compensate for the defective gene. If the normal gene is dominant over disease-causing gene, the effect of the disease-causing gene will be masked.

If that is the case, the allele for the genetic defect cannot be dominant, because the dominant allele will still expressed even if a normal gene is introduced.

Compensate 啫係點?我唔明分別喺係邊?


姐係類似抵消。唔同取代。
生活例子:你嘅長處抵消你嘅短處,唔代表你嘅短處消失左。

如果以 Sickle cell anaemia 為例,即係gene therapy 之後, sickle shaped RBC 依舊produce, 但係正常嘅 RBC 都會produce, 所以抵消左??


gene therapy 之後,the recessive gene for sickle cell anaemia will not be expressed. Therefore, all the RBC is normal.
2017-04-23 22:07:33
Why gene therapy cannot cure dominant disease?

You should bear in mind that the transferred normal gene is not a replacement of the defective gene. It is used to compensate for the defective gene. If the normal gene is dominant over disease-causing gene, the effect of the disease-causing gene will be masked.

If that is the case, the allele for the genetic defect cannot be dominant, because the dominant allele will still expressed even if a normal gene is introduced.

Compensate 啫係點?我唔明分別喺係邊?


姐係類似抵消。唔同取代。
生活例子:你嘅長處抵消你嘅短處,唔代表你嘅短處消失左。

如果以 Sickle cell anaemia 為例,即係gene therapy 之後, sickle shaped RBC 依舊produce, 但係正常嘅 RBC 都會produce, 所以抵消左??


因為有extra functional protein


唔係咁。
如果你所有bone marrow嘅cells都做gene therapy,所有RBC produced by the bone marrow都係正常。
2017-04-23 22:08:20
難怪巴打5**
我明白少少野
2017-04-23 22:09:10
Why gene therapy cannot cure dominant disease?

You should bear in mind that the transferred normal gene is not a replacement of the defective gene. It is used to compensate for the defective gene. If the normal gene is dominant over disease-causing gene, the effect of the disease-causing gene will be masked.

If that is the case, the allele for the genetic defect cannot be dominant, because the dominant allele will still expressed even if a normal gene is introduced.

Compensate 啫係點?我唔明分別喺係邊?


姐係類似抵消。唔同取代。
生活例子:你嘅長處抵消你嘅短處,唔代表你嘅短處消失左。

如果以 Sickle cell anaemia 為例,即係gene therapy 之後, sickle shaped RBC 依舊produce, 但係正常嘅 RBC 都會produce, 所以抵消左??


因為有extra functional protein


唔係咁。
如果你所有bone marrow嘅cells都做gene therapy,所有RBC produced by the bone marrow都係正常。

多謝巴打指正
我知我概念錯咩位 唔該
2017-04-23 22:10:08
Why gene therapy cannot cure dominant disease?

You should bear in mind that the transferred normal gene is not a replacement of the defective gene. It is used to compensate for the defective gene. If the normal gene is dominant over disease-causing gene, the effect of the disease-causing gene will be masked.

If that is the case, the allele for the genetic defect cannot be dominant, because the dominant allele will still expressed even if a normal gene is introduced.

Compensate 啫係點?我唔明分別喺係邊?


姐係類似抵消。唔同取代。
生活例子:你嘅長處抵消你嘅短處,唔代表你嘅短處消失左。

如果以 Sickle cell anaemia 為例,即係gene therapy 之後, sickle shaped RBC 依舊produce, 但係正常嘅 RBC 都會produce, 所以抵消左??


生活例子:你嘅長處抵消你嘅短處,唔代表你嘅短處消失左
長處=normal gene
短處=disease-causing gene
Since normal gene is dominant to the disease-causing gene, the disease-causing gene will still be present in the genome, but it will not express at all.
2017-04-23 22:11:29
越溫越頹,好想訓教
2017-04-23 22:12:18
Why gene therapy cannot cure dominant disease?

You should bear in mind that the transferred normal gene is not a replacement of the defective gene. It is used to compensate for the defective gene. If the normal gene is dominant over disease-causing gene, the effect of the disease-causing gene will be masked.

If that is the case, the allele for the genetic defect cannot be dominant, because the dominant allele will still expressed even if a normal gene is introduced.

Compensate 啫係點?我唔明分別喺係邊?


姐係類似抵消。唔同取代。
生活例子:你嘅長處抵消你嘅短處,唔代表你嘅短處消失左。

如果以 Sickle cell anaemia 為例,即係gene therapy 之後, sickle shaped RBC 依舊produce, 但係正常嘅 RBC 都會produce, 所以抵消左??


生活例子:你嘅長處抵消你嘅短處,唔代表你嘅短處消失左
長處=normal gene
短處=disease-causing gene
Since normal gene is dominant to the disease-causing gene, the disease-causing gene will still be present in the genome, but it will not express at all.

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