見你呢個算係最認真嘅comment我答多次
Virus嘅genomic materials 係除咗spike protein 仲有佢成個身嘅其他proteins. 佢地用你個細胞製造完就會resemble番個virus, 再走出個infected cell and then 去infect other cells. Virus 入細胞係require different parts on the capsule not the spike protein only.
mRNA vaccine唔同. 佢淨係encode左spike protein. 無入nucleus 所以個肌肉細胞死你個身體就少左啲細胞係express spike protein. 係肌肉細胞製造嘅spike protein大部份淨係會express 喺番that particular muscle cell嘅表面. 唔排除有啲會經exocytosis咁經exosomes secrete 走. 但係入到其他細胞都係lysosome 整爛晒, 唔會係其他細胞表面express. 一粒protein係唔會itself咁係個細胞到噴咗出嚟然後走去第二個位accumulate
mRNA唔stable 唔代表你打多啲就work. 成件事係要配合返有lipid nano particle (LNP). 要靠LNP先可以經endocytosis入細胞, 個lipid provide an appropriate charge比條mRNA可以做到lysosomal escape, 然後先function 到. 所以mRNA自己本身係入唔到你身體其他細胞做成影響.
俾返個Credit你, 其實一條mRNA可以製造幾多protein係長遠黎講如果我哋想expand 個technology 去做治療(vaccine唔算治療)係我地科學家要好嚴謹去解答嘅問題. 例如如果我哋想打啲encoded growth hormone嘅藥, 我地唔會想over express. 但係而家vaccine係only need to trigger adequate immune response. 個數唔洗好嚴謹. (當然我講嘅唔嚴謹唔代表求L其
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