早兩年我讀queen mary university of london 皮膚科文憑講嘅
或者你睇英國 BAD 嘅病人資訊
https://www.bad.org.uk/shared/get-file.ashx?id=155&itemtype=document
What is known about the long-term effects of calcineurin inhibitors?
When a drug such as a calcineurin inhibitor is taken by mouth it can lead to adverse effects because it suppresses the immune system. One possible consequence of immune suppression is an increased risk of non-melanoma skin cancer and lymphoma. When calcineurin inhibitors are applied topically the amount that is absorbed into the body is very much less than occurs after taking the drug by mouth. The amount of topical calcineurin inhibitor absorbed is less than 0.1 % of the applied dose. As a result, calcineurin inhibitors applied topically do not cause significant suppression of the immune system. There is no evidence from large epidemiological studies that topical calcineurin inhibitors are associated with an increased risk of lymphoma or non-melanoma skin cancer.