營養奶最好等佢真係食唔倒嘢先會好啲
(前列腺應該少啲呢個問題,除非到就黎走就可能會有食慾減低,但係都唔建議逼佢食野)
大路例如ensure加營素都好受歡迎
至於sex hormone 嘅藥基本上係抑制個腫瘤嘅生長
以下係GnRH agonist 嘅副作用:
Gonadotrophin-releasing hormone agonists (oncology)
For additional information see Gonadotrophin-releasing hormone agonists (endocrine), General principles: antineoplastics
Also known as luteinising hormone-releasing hormone (LHRH) agonists.
Goserelin (oncology)
Leuprorelin
Triptorelin
Mode of action
GnRH initially stimulates synthesis of FSH and LH, transiently increasing serum testosterone in males or serum estrogen in females. Continuous administration of GnRH agonists inhibits gonadotrophin production, suppressing ovarian and testicular steroidogenesis and inhibiting the growth of certain hormone-dependent tumours.
Indications
Prostate cancer
Breast cancer
Precautions
Risk factors for low BMD—GnRH agonists decrease BMD (see below).
Vertebral metastases—risk of spinal cord compression caused by tumour flare (below).
Risk factors for prolonged QT interval—due to testosterone suppression, GnRH agonists may prolong the QT interval but the clinical significance is unclear; correct risk factors if possible and use with caution.
Prostate cancer
In urinary tract obstruction there is a risk of acute bladder outlet obstruction or obstructive renal failure caused by tumour flare (below).
GnRH agonists may worsen control of diabetes; monitor and adjust dose of antidiabetic drugs if necessary.
Use cautiously where there are risk factors for cardiovascular disease (GnRH agonists may increase risk of cardiovascular disease, including coronary heart disease and MI).
Adverse effects
Common (>1%)
decreased BMD (below)
Prostate cancer: altered glucose tolerance, diabetes, anaemia, increased body fat, weight gain, muscle atrophy, hair changes (eg loss of body hair)
Infrequent (0.1–1%)
Prostate cancer: cardiovascular disease (eg coronary heart disease, MI)
Tumour flare
A flare may develop during the first 2 weeks of treatment, which may cause new or worsening signs and symptoms of prostate or breast cancer, eg increased bone pain. Spinal cord compression has also occurred.
In patients with prostate cancer, acute bladder outlet obstruction or obstructive renal failure have occurred. To prevent tumour flare in prostate cancer, start anti-androgens 1–2 weeks before the first dose of GnRH agonist and give for 1 month in total.
Decreased BMD
GnRH agonists decrease BMD. This was associated with an increased risk of fractures in men with prostate cancer. It is unclear whether the risk of fractures in premenopausal women with breast cancer is increased
(Australian medicine handbook 2019)
bmd 係bone mineral density.
醫生有無話會做化療/手術嗰啲?
知多啲個treatment plan可以講多啲要expect啲咩。
最後,加油
利申澳洲藥劑師