IVE 아이브 討論區 (4) 12月1日: 1st Single Album: ELEVEN
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牙奶似攰到眼都開唔大
條8k fancam好J到
中間有塊透明野
有官方粉絲名未？
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Pedo
A silver crosslinked injectable supramolecular CS–Ag hydrogel doped with bFGF (bFGF@CS–Ag) was fabricated as a novel wound healing scaffold to accelerate wound repair through dual release of antibacterial Ag+ and bFGF. Both in vivo acute wound and infected wound models were used to determine the healing efficiency of the obtained bFGF@CS–Ag hydrogel, followed by an investigation of the mechanism by which bFGF@CS–Ag accelerates wound repair. Compared to acute wound healing, the results showed that the bFGF@CS–Ag hydrogel exhibited more significantly enhanced wound regeneration towards infected wounds due to promotion of bFGF elution into the wound site resulting from the release of Ag+ from the CS–Ag hydrogel. Collectively, the data demon- strated that the bFGF@CS–Ag hydrogel exerts effective inhibition of bacterial growth and further promotes wound regeneration, including granulation deposition, collagen formation and re- epithelization in infected wounds. Moreover, due to the dual functionality of Ag+ and bFGF, bFGF@CS–Ag stimulates neovas- cularization, downregulation of pro-inflammatory TNF-a expres- sion, and polarization of macrophages to M2 phenotype macrophages with pro-healing properties. These findings indi- cate that the injectable supramolecular CS–Ag-based hydrogel system together with bFGF (bFGF@CS–Ag) is an alternative to traditional silver dressings and possesses great potential for broad spectrum in vivo applications, especially for infected chronic wounds.
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叫 Ronny 啦
叫 Ronny 啦
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