Similarly, neutralizing antibody responses were also significantly decreased for the Brazilian/Japanese P.1 strain (6.7-fold for BNT162b2, p < 0.0001; 4.5-fold for mRNA-1273, p < 0.001), which harbors three mutations in RBD (K417T, E484K, and N501Y) and has also been found in cases of re-infection (nuno_faria 2021).
Strikingly, neutralization of all three South African B.1.351 strains was substantially decreased for both 2-dose vaccines (v1: 34.5-fold for BNT162b2 and 27.7-fold for mRNA-1273; v2: 41.2-fold for BNT162b2 and 20.8-fold for mRNA-1273; v3: 42.4-fold for BNT162b2 and 19.2-fold for mRNA-1273; p < 0.0001 for all comparisons)
打兩針後對南非變種效力低42.4 倍,咁同無打有咩分別?

