人體的奧秘 - 兵仔是怎樣練成的

一連鳩頂

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一連鳩頂 2018-07-18 14:44:51
This time, I am going to talk about the thymus.
今次呢,我要講下胸腺 (thymus)。
Hah? What the fuck is thymus, is it eatable? I bet you to have this in your mind. I've already talked about bone, and hematopoiesis, i.e. blood cell formation. This includes leukocytes, i.e. white blood cells (WBCs), formation and thymus is exactly an immune organ related to WBCs.
胸腺?乜撚野胸腺?食得嫁?我敢打賭你一定咁唸😂咁我其實都已經講過骨頭啦,都知道骨頭同造血作用有關,所謂造血作用係唔單止造紅血球,重包埋白血球,而胸腺呢就正正係一個有關白血球製造既免疫系統器官。
Thymus is like a filter, filtering out self-attacking WBCs. However, not all WBCs go through the thymus. Only a special type called the T-lymphocyte (T stands for thymus), a kind of adaptive immunity cell, will go through the filter.
胸腺就好似一個過濾器,過濾一d會攻擊自己既白血球。之但係呢,唔係所有既白血球都由胸腺過濾,只有一隻特別白血球,叫胸腺淋巴球 (T-lymphocyte) 要通過胸腺依舊過濾器。
You may wonder why would we make self-attacking cells. If you want to find out, just read on~
或者你會唔明點解我地個身體會咁on9,整d攻擊自己既細胞,如果你想知點解,睇落去啦~
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Before talking about thymus, we need to locate it first.
睇下胸腺既位置先。

This is where the thymus locates, anterior to the heart and posterior to the sternum.
胸腺位於心臟既前面,胸骨 (sternum) 後面。
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The image shows an overview of the thymus. It has totally 2 lobes.
張圖可以見到成個胸腺既內部結構,我地總共有兩舊胸腺葉。
The thymus can be divided into 3 parts, capsule, cortex and medulla. The naming system quite similar to the kidney, if you remember.
胸腺主要可以分成3個部分,包膜 (capsule)、皮質 (cortex) 同埋髓質 (medulla)。命名既方法同腎都幾似,如果你記得既話。
The capsule is an epithelial layer surrounding the thymus.
包膜就係胸腺最外層既部分。
The cortex is the layer after the capsule, mainly immature T-lymphocytes can be found here.
包膜之後係皮質,依到有好多未成熟既胸腺淋巴球。
The medulla is the central part of the thymus. It is also the site for the maturation of T-lymphocytes.
胸腺既中間部分就叫髓質,依到就係胸腺淋巴球成熟既地方。
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There are mainly 2 kinds of cells in the thymus, the epithelial reticular cells and T-lymphocyte.
胸腺主要有兩種細胞,分別係頭先一直講既胸腺淋巴球同埋網狀上皮細胞 (epithelial reticular cell)。

Epithelial reticular cells are cells that construct the filtering network in the thymic medulla. It also presents self-substances, or self-antigens.
網狀上皮細胞就係過濾網既組成細胞,遍佈成個胸腺髓質。依D細胞會展示自體物質。
T-lymphocytes are adaptive immunity cells originated from the bone marrow.
胸腺淋巴球係運作標靶免疫力 (adaptive immunity) 既細胞,而佢係由來自骨髓既造血幹細胞轉化而成。
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It is time to get an idea of immunity. Although it is not very related to the thymus, but it is important in the understanding of the T-lymphocyte and the reasons for the existence of the thymus.
係時間認識一下免疫力。免疫力依個term我地就成日聽啦,但到底係咩野呢?雖然免疫力同胸腺既關係唔係好直接,但係認識左免疫力可以對有胸腺淋巴球更加好既了解,從而明白依個器官存在既目的。
We have 2 kinds of immunity, innate immunity (or non-specific immunity) and adaptive immunity (or specific immunity).
我地既免疫力主要可以分做兩種,分別係泛用免疫 (innate immunity) 同埋標靶免疫 (adaptive immunity)。
Innate immunity refers to immunity with non-specific targets, i.e. protect us from everything foreign, like our skin and inflammatory response. A wide range of protection means that it is less powerful.
泛用免疫力係指冇特定目標既免疫力,例如皮膚、炎症反應等等,佢地會防止一切對身體唔好既野,但廣泛既防護某程度上都代表住低效力。
Therefore, adaptive immunity is developed, it refers to immunity with specific targets, i.e. protect us from a specific pathogen. It is done by a specific type of cells called lymphocyte, which is a kind of WBC.
所以呢,我地就發展出標靶免疫啦。標靶免疫係指有特定目標既免疫力,基本上就係指由淋巴球 (lymphocyte) 建構出黎既免疫力,依種免疫會集中對付特定既目標。
一連鳩頂 2018-07-18 14:46:51
# Some details in lymphocytes
Lymphocytes can be futher categorized into B-lymphocyte and T-lymphocyte, which is named by where they matured, B for bone marrow (actually is Bursa of Fabricius, but who fucking cares, just some damn shit developments of the immunology. ) and T for thymus. Also, T-lymphocyte can be futher divided into T-helper lymphocyte and cytotoxic T-lymphocyte.
(i) T-helper lymphocyte - regulating the adaptive immune response.
(ii) Cytotoxic T-lymphcyte - launch immunity by killing an infected cell directly, or cell-mediated immunity.
(iii) B-lymphcyte - launch immunity by secreting specific antibodies, or humoral immunity. The B-cells that become 'antibodies factory' are also called plasma cells or effector B-lymphocyte. #
#識多小小淋巴球
淋巴球可以分做骨髓淋巴球 (B-lymphocyte) 同埋胸腺淋巴球,以佢地成熟既地方命名。而胸腺淋巴球又可以再細分為助手淋巴球 (T-helper lymphocyte) 同埋殺手淋巴球 (Cytotoxic T-lymphocyte)。
(壹) 助手淋巴球 - 調節標靶免疫
(貳) 殺手淋巴球 - 透過直接殺死目標黎執行標靶免疫,依一種標靶免疫又可以叫做細胞免疫 (cell-mediated immunity)
(參) 骨髓淋巴球 - 透過分泌抗體 (antibody) 執行標靶免疫,依一種標靶免疫又可以叫做抗體免疫 (humoral immunity) #


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At the begining of this article, I've asked the question about self-attacking WBCs. It's time to answer it.
記唔記得係文章既開頭,我問左一個有關自體攻擊既問題丫,學左咁多,依家係時候解答啦。
I've mentioned that lymphocytes are responsible in adaptive immunity, including T-lymphocytes and B-lymphocytes. To make it possible, we need to have the specialized lymphocyte be made before the infection, but it is not an easy job. There are varieties of pathogens in the world. In stead of making those lymphocytes one by one, which is inefficient, our bodies choose to make lymphocytes ramdomly, by ramdomly generate their receptors, and then wape out every self-attacking lymphocytes.
我地依家知道淋巴球,包括胸腺淋巴球同埋骨髓淋巴球,係負責標靶免疫既細胞啦。不過細心D唸下,要做到標靶免疫並唔容易,我地要係受特定病原體 (pathogens) 感染之前就整左負責對付特定病原體既淋巴球,而依個世界既病原體可以話係無限咁多種。如果我地既身體逐個逐個咁整D淋巴球,我地永遠無辦法追上病原體既總數,就算真係比你追到都十分之冇效率,所以呢,我地既身體並冇採用咁冇效率既方法,而用「隨機」依個方法,隨機咁整D淋巴球既受體 (receptor),再處理曬所有會同自體物質有反應既淋巴球。
This process is called the clonal selection (or central tolerance). In thymus, it is done by the epithelial reticular cells forming a filtering reticulum in medulla and presenting self-substances (or self-antigens). When the T-lymphocytes attach to the epithelial reticular cells, they will be programmed to death.
而依個過濾作用呢就叫做克隆選擇 (clonal selection)。係胸腺呢,網狀上皮細胞會係髓質形成過濾網,再係網入面展示盡量多既自體物質,當有胸腺淋巴球黐住左係D網狀上皮細胞,就會導向死亡。
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Let's take a look in the life of the T-lymphocyte.
黎睇下胸腺淋巴球既一生啦。
(1) Before the birth of the T-lymphocyte, some hematopoietic stem cells arrive thymus from bone marrow via blood stream. The hematopoietic stem cell resides in the thymus is called the thymic settling progenitors.
(This step is still under research, so it is questionable. )
(2) The thymic settling progenitor differentiates into the immature T-lymphocyte.
(3) The immature T-lymphocyte goes through central tolerance.
(4) If the immature T-lymphocytes can go through the central tolerance and squeezed out from the reticulum, they become mature T-lymphocyte (or naive T-lymphocyte, inactivated T-lymphocyte)
(5) The mature T-lymphocyte is sent to the lymph node via lymphatic duct and wait in it. That's why it is called lymphocyte as it is a cell that commonly found in lymph nodes.
(一) 胸腺淋巴球出現之前,骨髓入面既造血幹細胞經由血液進入胸腺。入左去胸腺既造血幹細胞又叫胸腺祖細胞 (thymic settling progenitor)。
(二) 胸腺祖細胞轉化做未成熟既胸腺淋巴球
(三) 未成熟既胸腺淋巴球接受克隆選擇。
(四) 如果未成熟既胸腺淋巴球成功通過克隆選擇,佢地就會再轉化為成熟左既胸腺淋巴球。
(五) 成熟左既胸腺淋巴球透過淋巴管被送到淋巴結 (lymph node),就係裡面等,就係因為咁淋巴先會有較高濃度既淋巴球,淋巴球個名都係咁得番黎。
一連鳩頂 2018-07-18 14:47:12
# Some details in lymphatic system
Lymphatic system is responsible for the reabsorption of leaked blood plasma. Lymphatic capillaries have big entries. And it is only allowed for entry except for the exits of the lymphatic system (at left and right subclavian veins) by some kinds of physical mechanism. Because of the big entries, it is also useful in the immune system and the digestive system.
(i) In digestive system, as chylomicrons are big molecules that can't enter blood capillaries, chylomicrons enter lacteal instead. (details in the article of 'small intestine')
(ii) In immune system, lymphocytes are also very big in sizes, so it is better to be transported via the lymphatic system.
Lymph node is like a police station during the way of the lymphatic duct, containing a lot of immune cells. #
#識多小小淋巴系統
淋巴系統最主要既作用其實係回收洩漏出黎既血漿。淋巴管有好大既入口,不過就被設計成入得唔出得,當然唔計淋巴系統既出口啦,係左同右既鎖骨下靜脈 (subclavian vein) 個鼠。就係因為依D大入口,淋巴系統都比左免疫系統同消化系統好多幫助。
(壹) 消化系統 - 因為乳糜微粒 (chylomicron) 好大粒,入唔到微絲血管,所以乳糜微粒只會進入乳糜管 (lacteal),一種淋巴管。(詳細內容睇番「基本既小腸介紹」)
(貳) 免疫系統 - 淋巴球都一樣好大粒,所以呢佢容易D進入淋巴系統。而淋巴結呢就好似淋巴管途中既警察局咁,裡面有好多既免疫細胞。#


(6) Once the mature T-lymphocyte meets its specialised pathogens, it is activated and start a whole bunch of immunity response.
(六) 當成熟左既胸腺淋巴球遇到會同佢發生反應既特定病原體,佢就會被啟動,再發生一連串既免疫反應。
The mature T-lymphocyte is also an naive T-lymphocyte in a different point of view, haha.
成熟左既胸腺淋巴球係另一個角度又叫做幼稚既胸腺淋巴球,呵呵。
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This is thymus, an organ with very few attention, like us. And where is my dear specialised T-lymphocyte?
就係咁啦,依個就係胸腺,一個完全不受重視既器官,就好似我地咁。唔知我幾時會搵到個舊特定既淋巴球呢?
一連鳩頂 2018-07-18 14:47:35
目錄
(1)基本既心臟介紹
lihkg.com/thread/649350
(2)基本既肺部介紹
lihkg.com/thread/652225
(3)基本既腎臟介紹
lihkg.com/thread/665504
(4)基本既胃部介紹
lihkg.com/thread/673704
(5)基本既小腸介紹
lihkg.com/thread/685309
(6)基本既大腸介紹
lihkg.com/thread/690908
(7)基本既肝臟介紹
lihkg.com/thread/696439
(8)基本既胰臟介紹
lihkg.com/thread/700041
(9)基本既骨頭介紹
lihkg.com/thread/714062
(10)基本既肌肉介紹
lihkg.com/thread/744825

建議由第一期開始慢慢睇
想睇最新目錄請自行起底去最新個post
歡迎留言 一齊討論 你問我唔一定會答
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No.4 2018-07-18 14:50:30
一連鳩頂 2018-07-18 19:29:40
屌下次唔用電腦po 個排版7到飛起
密過蜂巢
一連鳩頂 2018-07-18 23:38:24
講MHC又變chemistry ww

出面的確係咁樣譯冇錯,但冇意思,你都唔明佢想點,唔鍾意冇意思咁直譯

passive immunity 之後會再講 下個免疫器官XD
一連鳩頂 2018-07-18 23:47:36
BTW ching 你個邊都加油啊
黃雨啊…紅雨啊啊 2018-07-23 19:01:00
巴打,想問下咁會有咩原因令到胸線增生?之前我左眼眼皮有啲下垂,睇醫生懷疑有重症肌無力,入咗院check照胸就話見到我胸線好似有增生情況
親子王國國王👑 2018-07-23 19:02:31
正經學術post無人睇
一連鳩頂 2018-07-23 21:16:35
問到增生原因真係答唔到你

就好似問生cancer既原因咁

真係太多 太廣 咩都可以係原因咁濟

有時乜都冇做過都會中
一連鳩頂 2018-07-23 21:18:54
唉 睇黎做咩丫

反正冇用

正經野 邊及trash talk過癮

認真你就輸了丫嘛
高梧 2018-07-23 21:21:27
留名支持樓主
親子王國國王👑 2018-07-23 21:54:33
你啲post 我集集都有追 巴打咁有心去第二到發圍啦
唔好係兒登到浪費
一連鳩頂 2018-07-23 22:55:30
多謝支持啊

咁又唔會浪費 幾開心既 見到好多人鍾意自己既野

有機會再唸下其他平台 始終連登先係香港人既地方
SSAW 2018-07-24 09:32:04
見到巴打真係好有心

努力推動認真post風氣
加油
燒JER解難 2018-07-24 09:34:49
我都想問點解會生纖維瘤, 啲醫生都係話冇得解唔清楚原因, 但唔知呢啲纖維瘤未係瘤之前其實係咩嚟架呢??
一連鳩頂 2018-07-24 13:18:22
纖維基本上就係connective tissue 姐係締結組織

你可以唸做軟骨個款,硬d就係骨

本身依d組織都有細胞,當依d細胞亂咁增生,就會有個瘤係鼠
一連鳩頂 2018-07-24 13:21:11
最緊要有你地支持啊
冬秋夏春 2018-07-24 14:03:50
燒JER解難 2018-07-24 14:16:32
即係亂咁增生太厚所以硬咗變瘤???
一連鳩頂 2018-07-24 14:19:14
係啊 其實可以唸做connective tissue既cancer
燒JER解難 2018-07-24 14:20:25
但點解啲醫生又話冇咩唔會變真正乳癌?? 即係佢只會自己疊住生,唔會令到其他細胞都亂增生??
一連鳩頂 2018-07-24 17:24:55
所以先叫做benign tumors 姐係良性

其實都有惡性,不過小好多

始終connective tissue 本身冇咩血管會到
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