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//These studies found that after adjusting for important confounders (e.g., socioeconomic position), smokers who did not stop lost approximately 10 (men) to 11 (women) years of life expectancy [5, 6] compared with the earlier estimate of 6.5 years [2]. Women in 1996 smoked an average of 13.6 cigarettes per day [4]. Therefore, other things being equal, this would lead to an increase in the estimated loss of life expectancy per cigarette to 20 minutes overall: 17 minutes for men (11*10/6.5) and 22 minutes for women ((11*11/6.5)*(15.8/13.6); see supplementary file for a more detailed explanation of the calculation).//