只食半飽(50%~60%)的老鼠壽命會比食飽100%的老鼠更長,及老化速度較慢

18 回覆
9 Like 1 Dislike
2024-11-10 13:43:38
有無聽過有一系列實驗,係用老鼠食物份量同壽命/身體退化對比 (一系列實驗係指,唔係一班人做,而係好多班唔同的人分別做及前後唔同時間做)
大意係,將老鼠分組,一組係畀老鼠每日食足100%食物,另一組係畀老鼠每日只食到50%或60% 份量(我見到既係,唔知點解有d實驗用50%,有d用60%)
結果都係食少組(50%/60%)壽命明顯長左,及身體退化測試食少組比食飽組表現好。
但點壽命會長左/身體退化會慢左?原因不明。總之目前實驗顯示結果就係咁。
後來基因技術進步,我睇到一個實驗係,特登整d有 Alzheimer's disease(簡單而言係老人痴呆症)基因既老鼠出黎,再分組實驗
結果即使係有Alzheimer's disease基因既老鼠,只要佢食物量只有60%,佢地腦退化表現仍然係好過食足100%的正常老鼠的(用行為實驗測試的表現數據)

我唔係呢科既專業人士,請問有無人知道呢系列實驗既詳情?
又或者如果想上網search既話,應該用咩key words來search?

求有識之士指教!
2024-11-10 13:47:00
食多左野,要用多啲能量去消化,同你食太飽會眼訓一樣
2024-11-10 13:48:09





2024-11-10 13:49:04
有聽過一個理論係話飢餓感會令到身體自我淘汰一些壞細胞
2024-11-10 14:02:10
但應該有個balance 否則貧困地區咪玩哂
2024-11-10 14:02:42
日本的科學家大隅良典在2016年獲得了「諾貝爾醫學獎」 斷食會引發體內細胞進行「自體吞噬」 (autophagy) ,由來自日本的科學家大隅良典(Yoshinori Ohsumi) 教授進行研究之後,在2016年獲得了「諾貝爾醫學獎」,因為他發現人類如果適時的讓自己停止進食並維持飢餓,還很可能可以治療一些疾病。

講緊呢個?
2024-11-10 14:03:46
真架
2024-11-10 14:20:48
呢個應該係後來其中一個較合理解釋,具體解釋點解食半飽老鼠反而老化較慢及較長壽 (對比舊時只係猜想,可能食少d野,新陳代謝慢左,至老得較慢掛?但呢個當時只係猜想,無實質d的理據支持)
2024-11-10 14:22:45
未到六十歲唔好畀飽飯
2024-11-10 18:02:45
按照該系列實驗,若想減慢衰老速度,咁到左六十歲都唔好食飽飯
2024-11-10 18:47:36
唔想太長命
最好快啲死
日日食100%飽😎
2024-11-10 19:03:28
食幾多著幾多整定嘅
2024-11-10 20:07:07
樓主個claim 係未完全證實

https://pmc.ncbi.nlm.nih.gov/articles/PMC3299887/

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan
Wil

Laboratory survival experiments have shown that dietary restriction (DR) can increase median and maximum lifespan. This paper provides a meta-analysis of laboratory experiments that have evaluated the effects of DR on lifespan in rats and mice (1934 – present). In rats, DR increased median lifespan by 14 – 45% in half of all experiments, but in mice the effects of DR have been much weaker (4 – 27%). The least favorable effects of DR on lifespan have been observed among inbred rather than non-inbred mouse strains. In fact, some inbred mouse strains do not necessarily live longer with DR, including DBA/2 male mice and several strains from the ILSXISS recombinant inbred panel. Shortening of lifespan with DR has also been observed and confirmed for ILSXISS strain 114. Importantly, all rodent studies may be biased by the effects of laboratory breeding, since one study has shown that median lifespan is not improved by DR in wild-derived mice. These findings suggest that the set of genetic backgrounds studied in rodent DR experiments should be diversified. This will broaden the scope of genotypes studied in aging research, but may also be critical for translation of findings from rodents to historically outbred and genetically heterogeneous primate species.
2024-11-10 20:08:27
難怪男人短命啲
2024-11-10 22:35:35
犀利!
2024-11-10 23:50:54
諗下都知無可能
人體基礎代謝每日幾多+ 埋活動量計TDEE
有數得計
當我自己身高高肌肉量OK TDEE成3000
其實已經每餐都算食得幾飽足 先可能食夠或差唔多

如果食物份量變到得番5-6成 即係連基礎代謝既熱量都吸收唔到 想問下我點生存?
2024-11-11 18:52:33
佢地個計法唔係以基礎代謝來計100%或60%或50%
我理解中係,任食唔嬲(Ad libitum feeding)的情況下,老鼠會進食的份量為之100%。然後按此來計50%或60%份量。
(但我唔知我理解有無錯。求有識之士指教!)
2024-11-11 19:01:05
正常係,大陸d 親戚細個好窮個隻,去到80-90歲無病冇痛咁過身
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