《自然》期刊：漱口水能於30秒內殺死99.99% Covid-19病毒

全連登最靚仔巴 · 2022-03-01T19:50:40+08:00

睇咗少少論文，想同大家一齊分享吓用漱口水相信能有助減輕病情，甚至減低感染機會眾所周知，武肺病毒主要經口腔及鼻部入侵人體，由上呼吸道（口腔及咽喉等）延伸擴散至下呼吸道（氣管及肺部等）而omicron 主要係上呼吸道已經開始複製佢自己(Scudellari, 2022) 個人覺得如果中咗武肺嘅話我地自己手動係上呼吸道幫手殺吓d毒都幾好，叫做一定程度減低到身體嘅免疫系統負擔所以我去搵咗d論文睇，想知有咩有效鹽水毒就殺唔到，最多係幫手舒緩吓(Tiong et al., 2021) 但就發現0.34 M（即~2%濃度）鹽水有機會幫助抵擋病毒複製(in vitro)。另外高濃度鹽水亦有效透過抑制RNA同DNA嘅複製，從而加強表皮細胞(epithelial cells )嘅抗病毒能力。不過篇野就無指明係covid-19呢種武肺病毒（只係話包括229E呢種人類冠狀病毒）於是我自己另外再睇咗啲論文，搵到有科學家直接用Covid-19係Vero cells度做測試，發現鹽水喺1.5%時可以完全100%抑壓病毒嘅複製(Machado et al., 2021) 所以可能飲少量鹽水浪浪個咽喉都會有啲啲效，毒就殺唔到但就叫做可以抑制吓d 之後返咗去睇漱口水《自然》期刊中，有科學家發現，有cetylperidinium chloride同 hexetidine成分嘅漱口水可以於30秒內，殺滅99.99%嘅covid-19病毒(Tiong et al., 2021) 漱口個化驗用咗呢幾隻做，見到A,B同D都有效殺死covid 之後輾轉都搵到d中文資料美國南加大流行病學博士黃重德，日前發表另一則研究，進一步探討漱口水對預防病毒傳染的效果。他挑選了一群已經確診新冠肺炎的病患，讓他們每天使用濃度0.12%的氯己定葡糖酸鹽溶液漱口2次，持續4天後，再進行PCR檢測（檢體取自口咽）。他發現，有漱口的確診者裡，只剩下37.9%的PCR篩檢仍是陽性，剩下62.1%都是陰性反應；相較之下，沒有漱口的確診者中，只有5.5%呈陰性，其餘94.6%依然是陽性。研究分析，使用氯己定漱口，與防止新冠肺炎傳染間，可能存在相關性。不僅如此，該研究還針對另一群確診者，要求他們用氯己定漱口後，再加碼使用氯己定咽喉噴劑。結果發現，漱口加噴劑的人，只剩14%的PCR篩檢呈陽性；沒有使用任何氯己定的人，則有高達93.8%仍是陽性。（ source: https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.26954 ) 所以大家有需要或者都可以考慮用有關成分嘅漱口水浪口+飲少少2%左右嘅鹽水去幫吓身體但鹽水真係只飲小半杯去當殺吓d係咽喉附近嘅菌好了，飲得多身體會頂唔順當然我都有諗過用棉籤拎埋d漱口水去撩吓個鼻腔殺毒 30秒後再攞支濕水棉花棒捽返乾淨佢但好似有d癲（雖然依家個個都已經日撩夜撩） Anyway希望d資料有少少用 ————————————————————————————- Source: Machado, R., Glaser, T., Araujo, D., Petiz, L., Oliveira, D., & Durigon, G. et al. (2021). Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 Replication by Hypertonic Saline Solution in Lung and Kidney Epithelial Cells. ACS Pharmacology & Translational Science, 4(5), 1514-1527. doi: 10.1021/acsptsci.1c00080 Scudellari, M. (2022). Omicron’s Surprising Anatomy Explains Why It Is Wildly Contagious. Retrieved 1 March 2022, from <a rel="noopener noreferrer nofollow" href="https://www.scientificamerican.com/article/omicrons-surprising-anatomy-explains-why-it-is-wildly-contagious/" data-sr-url="https://r.lihkg.com/link?u=https%3A%2F%2Fwww.scientificamerican.com%2Farticle%2Fomicrons-surprising-anatomy-explains-why-it-is-wildly-contagious%2F&d=c%2FQNJ4nHfs1R8thiWZtrD0QtR7GNs0ijEplnmNBcRxc%3D&h=84d787d0" data-auto-link target="_blank">https://www.scientificamerican.com/article/omicrons-surprising-anatomy-explains-why-it-is-wildly-contagious/ Tiong, V., Hassandarvish, P., Bakar, S., Mohamed, N., Wan Sulaiman, W., & Baharom, N. et al. (2021). The effectiveness of various gargle formulations and salt water against SARS-CoV-2. Scientific Reports, 11(1). doi: 10.1038/s41598-021-99866-w

林寶堅離 2022-03-01 21:24:29

想飲

DVD_ROM 2022-03-01 21:27:18

聽日漱口水全城清貨

存倉TQQQ 2022-03-01 21:27:51

遲啲全城瘋搶漱口水

chiquitita 2022-03-01 21:28:02

日本細路出完街要漱口

毛賊神經病 2022-03-01 21:30:48

聽日又有人去搶嗽口水

啤啤啤啤牌樣 2022-03-01 21:32:33

聽日漱口水又無晒

拉爾拿 2022-03-01 21:33:05

lm

大陽能電筒 2022-03-01 21:34:01

鑒股知陰 2022-03-01 21:34:45

Vodka有無用

Porzingis#6 2022-03-01 21:34:59

你輸得林又要清0

支人說夢 2022-03-01 21:42:13

從而
從而
從而

罪名成立

樓主準備偷渡潛逃未？

努力的長期病人 2022-03-01 21:45:56

精子殺covid

留情不能 2022-03-01 21:45:58

題目誤導? Journal of Medical Virology 點解會譯做自然期刊? 點解唔係「醫療病毒學期刊」? Nature 係另一本喎師兄?

李維斯 2022-03-01 21:50:01

係咪要長期含住漱口水？
但照空氣傳播摸眼耳鼻咪又係中

太史五蛇羹 2022-03-01 21:58:40

維尼大都督 2022-03-01 21:58:42

用黎洗鼻會點

乜77 2022-03-01 21:59:29

剛剛朋友回報超市無晒

魯振盪時間 2022-03-01 22:01:15

仆街又要搶漱口水

剩下一個我 2022-03-01 22:12:03

屌佢老母呢幾日屈臣冇哂...

蔣浿濤 2022-03-01 22:13:39

Pcr test 係做鼻同喉，漱口水理論上只清理口腔，都可以對pcr test 有咁大影響？

屍臭之路 2022-03-01 22:18:36

另外高濃度鹽水亦有效透過抑制RNA同DNA嘅複製，從而加強表皮細胞(epithelial cells )嘅抗病毒能力。

原理:

In the presence viral infection and the availability of NaCl, cells utilise the chloride ions to produce hypochlorous acid (HOCl). Since HOCl is the active ingredient in bleach, which is known to have an antiviral effect, the mechanism could be augmented by supplying chloride ions through NaCl to treat infections.

普通感冒時，用高濃度NaCl 洗鼻和漱口的效果:

Follow up data was available from 61 (Intervention:30, Control:31). 87% found HSNIG acceptable, 93% thought HSNIG made a difference to their symptoms. In the intervention arm, duration of illness was lower by 1.9 days (p = 0.01), over-the-counter medications (OTCM) use by 36% (p = 0.004), transmission within household contacts by 35% (p = 0.006) and viral shedding by ≥0.5 log10/day (p = 0.04).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355924/

問題係點樣維持呢個濃度。你自己啲分泌物會稀釋啲鹽水。你physiological saline conc. 一般只係0.9% w/v NaCl

他挑選了一群已經確診新冠肺炎的病患，讓他們每天使用濃度0.12%的氯己定葡糖酸鹽溶液漱口2次，持續4天後，再進行PCR檢測（檢體取自口咽）。

但呢到Study population係確診者，而唔係無中嘅人。佢可能可以減低病忠傳俾人嘅機率，但對於健康嘅人唔一定有太大影響。同埋佢都係漱口而唔係飲。

你一日有十幾分鐘無病毒唔代表你唔會感染肺炎，亦唔代表呢樣係一個有效預防肺炎嘅做法。

你就咁用水漱口可能重更加有效。

Gargling
Frequent gargling with water may help reduce episodes of upper respiratory tract infection, but evidence is limited to a single study. The well-designed RCT involved 387 adults randomly assigned to gargling with water, gargling with a diluted povidone–iodine solution or usual care (control).37 Gargling with the povidone–iodine solution had no effect, whereas gargling with water was effective in reducing the risk of an upper respiratory tract infection (30.1% v. 40.8% in the control group; p = 0.044), for a number needed to treat of 10. The degree of gargling required was considerable (20 mL for 15 seconds repeated three times, performed three times daily). Confirmation from a second RCT would be helpful before recommending gargling.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928210/

呢到用Povidone-Iodine (PVP-I)做比較，即係講緊betadine (樓上已經有人提)。PVP-I 自己已經有virucidal 嘅能力去殺武漢病毒。

PVP-I at a concentration >0.5 mg/ml in contact with SARS-CoV-2 for 30 s, 1 min, 2 min and 5 min showed up to 99% viral inhibition.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689632/

結論: 用水漱口好過。

不漏洞奶奶 2022-03-01 22:20:50

好誤導, in vitro就話得啫, in vivo係第二個世界

發夢見到 2022-03-01 22:26:05

ミライへ 2022-03-01 22:33:53

係所以滴喉嚨乜都死

《自然》期刊：漱口水能於30秒內殺死99.99% Covid-19病毒

全連登最靚仔巴