Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.
Conclusion
This observation, which has been posted as a pre-print on the SSRN platform (18), suggests that vaccination with the BNT162b2 mRNA vaccine might induce rapid progression of AITL. Dedicated studies are needed to determine whether this case can be extrapolated to populations of patients with AITL or other peripheral T cell lymphoma involving TFH cells.
https://www.frontiersin.org/articles/10.3389/fmed.2021.798095/full
AITL (angioimmunoblastic T-cell lymphoma)，即血管免疫芽細胞性 T 細胞淋巴瘤，乃惡性腫瘤。五年存活率只有三成多
http://www.tsim.org.tw/journal/jour27-3/04.PDF
苖撚唔洗咁寸。睇你惡得幾耐
