唔認為呢單野告得入
非麻醉科醫生施行丙泊酚鎮靜
Non-anesthesiologist–administered propofol sedation (NAAP)
For
unselected procedures and patients, three studies were found:
▶ A meta-analysis of 22 RCTs that compared
propofol monotherapy versus traditional sedation (
1798 patients) for GI endoscopy has been added to● " Table 1; it found shorter recovery and discharge periods, higher post-anesthesia recovery scores, better sedation, and greater patient cooperation with propofol monotherapy compared with traditional sedation, with no increase in cardiopulmonary complications [18]. The healthcare category of the provider of propofol sedation was not mentioned.
▶ Two prospective, multicenter, non-comparative, surveys from Germany that globally involved
> 200 000 patients found a low incidence of propofol-related complications: one survey analyzed
endoscopist-administered propofol sedation and reported
major adverse events (mask ventilation and laryngospasm) in 0.016 % of patients [19]; in the other study, NAAP was used for sedation in > 90 % of cases, it reported
clinically relevant sedation-related complications (defined as respiratory insufficiency that required mechanical ventilation and/or caused hospitalization or prolongation of hospital stay) in
0.042 % of patients and
sedation-related death in 0.003 % (not 0.00042 % and 0.00003 % as miscalculated by the authors) [20].
For advanced endoscopic procedures, three meta-analyses were found:
▶ A meta-analysis of 26 prospective observational trials that compared
propofol sedation administered by a non-anesthesia provider versus an anesthesia provider in > 5000 advanced endoscopic procedures (EUS, ERCP, and deep small-intestinal enteroscopy) [21]. NAAP was associated with similar safety but lower patient and endoscopist satisfaction compared with anesthesia provider-administered propofol sedation.
▶ Two meta-analyses compared propofol versus traditional sedation, either for advanced endoscopic procedures in general (9 RCTs, 969 patients) [22] or for ERCP alone (6 RCTs, 663 patients) [23].
Propofol was administered by a non-anesthesiologist in 7 of the 9 RCTs including advanced procedures and 3 of the 6 RCTs on ERCP. Both studies found that propofol sedation was associated with a shorter recovery time and a similar incidence of cardiopulmonary adverse events; additionally the largest study found that propofol was associated with a better sedation and amnesia level. The duration of ERCP was similar with propofol versus traditional sedation.
[
Non-anesthesiologist administration of propofol for gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates
DOI http://dx.doi.org/ 10.1055/s-0034-1393414 Published online: 12.11.2015 Endoscopy 2015; 47: 1175– 1189es Guideline – Updated June 2015